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HIV and AIDS - Treatment in India

University of Pittsburgh USA Develops Test to Detect Hidden HIV

How do doctors/researchers determine if someone is cured of HIV? A new University of Pittsburgh USA Pitt Public Health test may solve the problem efficiently and inexpensively.

The method to develop a cure for HIV has long been curse by a apparently simple question: How do doctors /researchers determine if someone is cured from HIV? The HIV has a talent for lying asleep in immune cells at levels unnoticeable to all but the most expensive and time-consuming medical tests.

Scientists / researchers at the University of Pittsburgh’s USA Graduate School of Public Health notify in Nature Medicine that they have designed a medical test sensitive enough to detect “hidden” HIV, and quick, less labour and cost effective than the current “gold standard” test.

The new Pitt test also disclose that the amount of virus hiding dormant in patient who appears to be closely cured of HIV is about 70-times larger than past estimates. “In the whole world there are substantial efforts to cure patients of HIV by finding treatment to eradicate this dormant reservoir of HIV that unmoving continue in patients, despite our best ART therapies,” said senior author Phalguni Gupta, Ph.D., professor and vice chair of Pitt Public Health’s Department USA of Infectious Diseases and Microbiology. “But these efforts to eradicate HIV aren’t going to grow if we don’t have medical tests that are very sensitive and practical enough to tell doctors / researchers if someone is truly cured of HIV.”

Till date, the best test available to check HIV is called a “quantitative viral outgrowth assay,” or Q-VOA. Q-VOA test has many snags: Q-VOA may provide only a minimal estimate of the size of the latent HIV reservoir; This test requires a large volume of blood; and is labor-intensive, time-consuming and very expensive blood test.

This latest TZA blood test produces great results in one week as compared to the two weeks required by using the Q-VOA, and at very affordable cost. This TZA blood test requires a much smaller volume of blood sample and is less labor-intensive.

The advancement in technology explains and confirms that HIV Proviral DNA is a very important tool to determine the dormant reservoir virus which is very important to calculate whether the HIV patient under the treatment is really negative and cured from HIV.